全文获取类型
收费全文 | 7353篇 |
免费 | 379篇 |
国内免费 | 65篇 |
学科分类
医药卫生 | 7797篇 |
出版年
2023年 | 48篇 |
2022年 | 50篇 |
2021年 | 181篇 |
2020年 | 155篇 |
2019年 | 148篇 |
2018年 | 200篇 |
2017年 | 142篇 |
2016年 | 192篇 |
2015年 | 205篇 |
2014年 | 290篇 |
2013年 | 345篇 |
2012年 | 615篇 |
2011年 | 602篇 |
2010年 | 318篇 |
2009年 | 333篇 |
2008年 | 520篇 |
2007年 | 497篇 |
2006年 | 477篇 |
2005年 | 478篇 |
2004年 | 409篇 |
2003年 | 393篇 |
2002年 | 363篇 |
2001年 | 60篇 |
2000年 | 43篇 |
1999年 | 59篇 |
1998年 | 61篇 |
1997年 | 49篇 |
1996年 | 39篇 |
1995年 | 51篇 |
1994年 | 32篇 |
1993年 | 41篇 |
1992年 | 55篇 |
1991年 | 31篇 |
1990年 | 35篇 |
1989年 | 46篇 |
1988年 | 32篇 |
1987年 | 27篇 |
1986年 | 21篇 |
1985年 | 16篇 |
1984年 | 12篇 |
1983年 | 14篇 |
1982年 | 10篇 |
1981年 | 7篇 |
1980年 | 20篇 |
1979年 | 9篇 |
1978年 | 6篇 |
1976年 | 4篇 |
1974年 | 8篇 |
1971年 | 6篇 |
1968年 | 4篇 |
排序方式: 共有7797条查询结果,搜索用时 15 毫秒
61.
The successful management of a Bronchoesophageal fistula after lung transplantation: a case report 下载免费PDF全文
Stefania Camagni Alessandro Lucianetti Paolo Ravelli Giovanni B. Di Dedda Ezio Bonanomi Vittorio Corno Alessandro Aluffi Domenico Pinelli Marco F. Zambelli Michela Guizzetti Piercarlo Parigi Michele Colledan 《Transplant international》2015,28(7):884-887
We describe an unprecedented, disastrous complication after bilateral lung transplantation (BLT), a bilateral bronchial dehiscence with a right bronchoesophageal fistula leading to life‐threatening septic shock. We also report the successful endoscopic management of this complication by double stenting and stress the efficacy of the multidisciplinary approach to this critical case. 相似文献
62.
Xanthopoulou Penny D. Mbanu Jennifer Chevalier Agnes Webber Martin Giacco Domenico 《Community mental health journal》2022,58(7):1338-1345
Community Mental Health Journal - This paper explores the subjective experiences of mental health practitioners, people with psychosis and carers, on social isolation and community integration of... 相似文献
63.
Korda Athanasia Zamaro Ewa Wagner Franca Morrison Miranda Caversaccio Marco Domenico Sauter Thomas C Schneider Erich Mantokoudis Georgios 《Journal of neurology》2022,269(3):1396-1403
Journal of Neurology - Skew deviation results from a dysfunction of the graviceptive pathways in patients with an acute vestibular syndrome (AVS) leading to vertical diplopia due to vertical ocular... 相似文献
64.
Gembillo Guido Siligato Rossella Cernaro Valeria Satta Ersilia Conti Giovanni Salvo Antonino Romeo Adolfo Calabrese Vincenzo Sposito Giovanna Ferlazzo Guido Santoro Domenico 《International urology and nephrology》2022,54(2):395-403
International Urology and Nephrology - Inflammation, oxidative stress (OS), atherosclerosis and resistant hypertension (RH) are common features of chronic kidney disease (CKD) leading to a higher... 相似文献
65.
66.
Arba Francesco Vit Federica Nesi Mascia Rinaldi Chiara Silvestrini Mauro Inzitari Domenico 《Neurological sciences》2022,43(1):139-152
Neurological Sciences - Carotid atherosclerosis is a pathological process that leads to narrowing of the vessel lumen and a consequent risk of stroke. Revascularization procedures such as carotid... 相似文献
67.
Antonietta Gigante Domenico Margiotta Luca Navarini Biagio Barbano Maria L. Gasperini Claudia D'Agostino Antonio Amoroso Antonella Afeltra Edoardo Rosato 《International wound journal》2018,15(3):424-428
Patients with systemic sclerosis (SSc) are at a high risk of the development of ischaemic digital ulcers (DUs) that can be complicated with infections, gangrene, and osteomyelitis. The aim of this study is to evaluate the role of endostatin in scleroderma DUs.In total, 90 SSc patients were enrolled in this study. Serum endostatin levels and DU assessment were determined in all SSc patients. The serum levels of endostatin significantly increased with progression of capillaroscopic damage (P < .01). The serum levels of endostatin are significantly (P < .05) higher in SSc patients with new DUs than in SSc patients without new DUs (127 ± 31.1 ng/mL vs 116.3 ± 39.7 ng/mL). The Receiver Operating Characteristic (ROC) curves demonstrated good accuracy of new DU prediction for the serum level of endostatin (0.70, P < .01 [95% confidence interval (CI) 0.59‐0.81]). Using a cut‐off value of 116 ng/mL, the odds ratio was 2.609 (CI 1.075‐6.330, P < .05). The serum levels of endostatin are significantly (P < .01) higher in SSc patients with infected DUs than in SSc patients without infected DUs (139.2 [114.6‐340.91] ng/mL vs 117.5 [64.3‐163.9] ng/mL). Serum levels of endostatin are higher in patients with DUs, especially in those with infected DUs. 相似文献
68.
Marco Vito Marino Mauro Podda Marcos Gomez Ruiz Carmen Cagigas Fernandez Domenico Guarrasi Manuel Gomez Fleitas 《Journal of robotic surgery》2020,14(3):493-502
Robotic-assisted pancreaticoduodenectomy (RPD) is progressively gaining momentum. It seems to provide some potential advantages over open approach. Unfortu 相似文献
69.
Fanny Lebreton Kevin Bellofatto Charles H. Wassmer Lisa Perez Vanessa Lavallard Graldine Parnaud David Cottet‐Dumoulin Julie Kerr‐Conte Franois Pattou Domenico Bosco Vronique Othenin‐Girard Begoa Martinez de Tejada Ekaterine Berishvili 《American journal of transplantation》2020,20(6):1551-1561
Hypoxia is a major cause of considerable islet loss during the early posttransplant period. Here, we investigate whether shielding islets with human amniotic epithelial cells (hAECs), which possess anti‐inflammatory and regenerative properties, improves islet engraftment and survival. Shielded islets were generated on agarose microwells by mixing rat islets (RIs) or human islets (HI) and hAECs (100 hAECs/IEQ). Islet secretory function and viability were assessed after culture in hypoxia (1% O2) or normoxia (21% O2) in vitro. In vivo function was evaluated after transplant under the kidney capsule of diabetic immunodeficient mice. Graft morphology and vascularization were evaluated by immunohistochemistry. Both shielded RIs and HIs show higher viability and increased glucose‐stimulated insulin secretion after exposure to hypoxia in vitro compared with control islets. Transplant of shielded islets results in considerably earlier normoglycemia and vascularization, an enhanced glucose tolerance, and a higher β cell mass. Our results show that hAECs have a clear cytoprotective effect against hypoxic damages in vitro. This strategy improves β cell mass engraftment and islet revascularization, leading to an improved capacity of islets to reverse hyperglycemia, and could be rapidly applicable in the clinical situation seeing that the modification to HIs are minor. 相似文献
70.
Rita Lombardi Maura Sonego Biagio Pucci Laura Addi Federica Iannelli Francesca Capone Luigi Alfano Maria Serena Roca Maria Rita Milone Tania Moccia Alice Costa Elena Di Gennaro Francesca Bruzzese Gustavo Baldassarre Alfredo Budillon 《Molecular oncology》2021,15(4):1005
Acquired resistance to platinum (Pt)‐based therapies is an urgent unmet need in the management of epithelial ovarian cancer (EOC) patients. Here, we characterized by an unbiased proteomics method three isogenic EOC models of acquired Pt resistance (TOV‐112D, OVSAHO, and MDAH‐2774). Using this approach, we identified several differentially expressed proteins in Pt‐resistant (Pt‐res) compared to parental cells and the chaperone HSP90 as a central hub of these protein networks. Accordingly, up‐regulation of HSP90 was observed in all Pt‐res cells and heat‐shock protein 90 alpha isoform knockout resensitizes Pt‐res cells to cisplatin (CDDP) treatment. Moreover, pharmacological HSP90 inhibition using two different inhibitors [17‐(allylamino)‐17‐demethoxygeldanamycin (17AAG) and ganetespib] synergizes with CDDP in killing Pt‐res cells in all tested models. Mechanistically, genetic or pharmacological HSP90 inhibition plus CDDP ‐induced apoptosis and increased DNA damage, particularly in Pt‐res cells. Importantly, the antitumor activities of HSP90 inhibitors (HSP90i) were confirmed both ex vivo in primary cultures derived from Pt‐res EOC patients ascites and in vivo in a xenograft model. Collectively, our data suggest an innovative antitumor strategy, based on Pt compounds plus HSP90i, to rechallenge Pt‐res EOC patients that might warrant further clinical evaluation. 相似文献